Gentrifi cation and segregation are complex and controversial urban phenomena of social and spatial differentiation at global scale. Similar to other Latin American megacities, Santiago, Chile has undergone a rapid urban expansion with social disparities. Specifi cally, in recent decades, real estate development has modifi ed the urban lifestyle in peri-central and peripheral areas, producing a geographical proximity between low and high-income residents that needs to be debated. However, these socio-spatial transformations appear to have lost sight of the original urban fabric, as well as people’s values and collective memories. Which typological and topological effects can be recognized in Santiago’s peri-central and peripheral zones as a result of these changes? Based on a contextual, theoretical and empirical analysis, we discuss the socio-spatial transformations of two neighborhoods in Santiago, Chile: El Llano Subercaseaux (a historical peri-central neighborhood) and Parque Violeta Cousiño (an emergent neighborhood on the city’s periphery). The research findings, which are systematized by a topological and typological matrix, provide conclusions about trends in peri-central Latino gentrification and peripheral polarization.